Matrix Proteins and Proteinases Network in Human Cardiovascular Diseases Explored By Cytoscape
نویسندگان
چکیده
منابع مشابه
Generation and degradation of human endostatin proteins by various proteinases.
The angiogenesis inhibitor endostatin is a fragment of the NC1 domain of collagen XVIII. The generation of endostatin has been investigated only in murine hemangioendothelioma cell cultures and was ascribed to cathepsin L. Distinct endostatin-like fragments were detected in human tissues and serum. To identify proteinases able to generate such fragments, we incubated human NC1 with proteinases ...
متن کاملMultiple Secretion of Matrix Serine Proteinases by Human Gastric Carcinoma
Proli'¡misespecies secreted by 10 human gastric carcinoma cell lines were analyzed by gelatin zymography and immunoblotting. These cell lines were classified into the following three groups with respect to proteinase secretion: cell lines secreting mainly gelatinases A and/or B; those secreting multiple types of serine proteinases; and those scarcely secreting these enzymes. Two cell lines of ...
متن کاملActivation of human matrix metalloproteinases by various bacterial proteinases.
Matrix metalloproteinases (MMPs) are zinc-containing proteinases that participate in tissue remodeling under physiological and pathological conditions. To test the involvement of bacterial proteinases in tissue injury during bacterial infections, we investigated the activation potential of various bacterial proteinases against precursors of MMPs (proMMPs) purified from human neutrophils (proMMP...
متن کاملPrediction of Cardiovascular Diseases Using an Optimized Artificial Neural Network
Introduction: It is of utmost importance to predict cardiovascular diseases correctly. Therefore, it is necessary to utilize those models with a minimum error rate and maximum reliability. This study aimed to combine an artificial neural network with the genetic algorithm to assess patients with myocardial infarction and congestive heart failure. Materials & Methods: This study utilized a m...
متن کاملNetwork propagation in the cytoscape cyberinfrastructure
Network propagation is an important and widely used algorithm in systems biology, with applications in protein function prediction, disease gene prioritization, and patient stratification. However, up to this point it has required significant expertise to run. Here we extend the popular network analysis program Cytoscape to perform network propagation as an integrated function. Such integration...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Research Ideas and Outcomes
سال: 2016
ISSN: 2367-7163
DOI: 10.3897/rio.2.e9617